We work across all preclinical imaging

modalities including optical, PET/SPECT/CT,

MRI and photo acoustic.

Our Mission

In Vivo Concepts is deeply concerned about waste anesthesia gas exposure to researchers. For too long, this issue has been overlooked as a “minor nuisance” during small animal surgical procedures and imaging experiments. Unfortunately, repeated exposure of lab personnel has serious health consequences and has been a focus of Environmental Health and Safety (EHS) offices in the past five years. IVC’s mission is to eradicate waste gas exposure, and bring laboratories into compliance with EHS guidelines.

Who We Are

In Vivo Concepts was originally launched in 2014 by researchers from the Univesity of Notre Dame that sought to design and produce gas anesthesia manifolds for advanced imaging procedures. The founders quickly realized that several core problems in pre-clinical anesthesia space needed addressed to improve lab safety, improve mouse positioning, and improve the efficiency of delivery. Since launch, IVC has commercialized over 15 product lines that have been sold into 1000s of worldwide laboratories to the benefit of researchers, mice, and even lab budgets.

Our Technology

IVC technology addresses three main problems within the pre-clinical anesthesia delivery space. First, the efficiency of delivery to multiple ports is dramatically enhanced by our patented hyperbranching technology, such that equal flows of gas evenly distributed. This has two practical outcomes: 1) Animal awakening at distal ports is dramatically reduced, and 2) Lower overall gas flows are needed, saving research funds on isoflurane and gas tank usage.

Next, the hyperbranching strategy is also utilized to route active scavenging ports to the periphery of each nose cone, such that waste gas is scavenged (under vacuum) before it leaves the port. The technology was validated to scavenge 99.999% of waste gas during studies at NIH. Finally, ergonomics are vastly improved since the animals lay in a natural, flat position. As a bonus, numerous other features have been implemented for imaging, including optically silent plastics, unobstructed views of the specimen from above and below, facile imaging of up to 10 mice, and the creation of HEPA filtered control chambers.

Our Products

  • MiniFlow
  • UniFlow
  • NRBFlow
  • EquaFlow 5M (Patent 1)
  • EquaFlow LP
  • EquaFlow 3i
  • EquaFlow 3XL
  • EquaFlow 10
  • EquaFlow XRAD10
  • AquaFlow
  • MultiFlow
  • TetraFlow
  • SomniFlow
  • Imaging Phantoms
  • RojoFlow
  • MouseTaxicFlow
  • RatTaxicFlow